The Gary Null Show Notes – 03.20.23

Videos:

2. NAC–(N-Acetylcysteine) Potent Antioxidant and Anti-Inflammatory (5:09)
3. Nattokinase and blood pressure – Video abstract [99553] (2:40)
4. Can Nattokinase Help Break Down ‘Microclots’? | With Prof Resia Pretorius & Prof Doug Kell (5:23)
5. Destroying spike protein! – COVID-19 update 60 (5:49)
6. Why are all our young men being demonised? | SpectatorTV (3:00)
7. Jon Stewart SMEARED As RACIST And ALT-RIGHT After Coming Out Pro-Lab Leak Theory: Brie & Robby REACT (9:32)
8. “Arrested for a social media post” | Konstantin Kisin (5:00)
9. Consistency over war crimes? – TD Richard Boyd Barrett (6:21) part 2

  1. 10. IRISH MP HUMILIATES ISRAELI AMBASSADOR – EPIC (2:47) part 1 

11. JUST IN: Rand Paul Directly Confronts Top Biden Official On Funding Virus Studies In China (5:37)
12. COVID Amnesty for Decision Makers? (3:00)
13. Neil Oliver: Many are speculating that a final and catastrophic CRASH is coming for the banks…(11:12)

  1. 14. ‘DO YOU SAY YOU DON’T KNOW?’ Josh Hawley SHREDS Garland with ‘lying’ CHARGE after ‘parents’ a.rrest (8:06)
  1. 15. MEP Clare Daly is indignant about armchair warmongering cheerleaders for Ukraine (1:27)

Colon cancer patients who eat nuts have lower death riskYale University, March 2nd, 2018 

People with stage III colon cancer who regularly eat nuts are at significantly lower risk of cancer recurrence and mortality than those who don’t, according to a new study.

The study followed 826 participants in a clinical trial for a median of 6.5 years after they received treatment with surgery and chemotherapy. Those who regularly ate at least two, one-ounce servings of nuts each week demonstrated a 42 percent improvement in disease-free survival and a 57 percent improvement in overall survival.

“Further analysis of this cohort revealed that disease-free survival increased by 46 percent among the subgroup of nut consumers who ate tree nuts rather than peanuts,” says Charles S. Fuchs, director of the Yale University Cancer Center and senior author of the study. Tree nuts include almonds, walnuts, hazelnuts, cashews, and pecans, among others. In contrast, peanuts are actually in the legume family of foods.

Additionally, the researchers emphasize, the study highlighted connections between biological mechanisms that worsen disease not just in colon cancer but in certain chronic illnesses such as type 2 diabetes.

Earlier research among patients with colon cancer revealed that people had worse outcomes when they had lifestyle factors—such as obesity, lack of exercise, and a diet with high levels of carbohydrates—that heighten insulin resistance and quickly raise levels of blood sugar.

Nuts also might play a positive role by satisfying hunger with less intake of carbohydrates or other foods associated with poor outcomes, Fuchs notes.

Patients may not be eating nuts due to concerns about the high fat content, says Fuchs. For example, a one-ounce serving of about 24 almonds holds about 200 calories, including 14 grams of fat.

“People ask me if increasing nut consumption will lead to obesity, which leads to worse outcomes,” he says. “But what’s really interesting is that in our studies, and across the scientific literature in general, regular consumers of nuts tend to be leaner.”

Exercise could fortify immune system against future cancers

University of Nebraska Medical Center, March 11, 2023

A preliminary study suggests that when cancer survivors exercise for several weeks after they finish chemotherapy, their immune systems remodel themselves to become more effective, potentially fending off future incidences of cancer. The finding may help explain why exercise can significantly reduce the chances of secondary cancers in survivors or reduce the chances of cancer altogether in people who have never had the disease.

Laura Bilek, Graham Sharp, and Geoffrey Thiele, all of the University of Nebraska Medical Center analyzed T cells in the blood of cancer survivors before and after a 12-week exercise program. They found that a significant portion of these immune cells converted from a senescent form, which isn’t as effective at combating disease, to a naïve form, ready to fight cancer and infections.

Study leader Laura Bilek explains that previous research had turned up a variety of positive associations between exercise and cancer—notably, that exercise can reduce the risk of getting initial incidences of several different types of cancers, can often improve prognosis in cancer patients, and can reduce the risk of recurrence and secondary cancers survivors of some types of cancers. However, the mechanism behind these phenomena has been unknown.

Working with a group of 16 cancer survivors, all but one of who recently finished chemotherapy cancer treatment, the researchers focused on T cells, a type of immune cell that attacks a variety of infectious agents as well as cancer cells. After chemotherapy, previous research had shown that the majority of T cells become senescent, with a decreased ability to fight infections and cancers. However, Bilek says, rebuilding the population of responsive (naïve) T cells is critical for regaining normal immune function and cancer-fighting ability.

Results showed that the ratio of senescent to naïve T cells changed favorably in the majority of participants, with most of the study subjects regaining greater numbers of the naïve variety.

“What we’re suggesting is that with exercise, you might be getting rid of T cells that aren’t helpful and making room for T cells that might be helpful,” Bilek says.

Short night-time sleep linked with nearly doubled risk of clogged leg arteries

Karolinska Institute (Sweden), March 17, 2023

Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease (PAD) compared with seven to eight hours. That’s the finding of a study published in European Heart Journal—Open.

“Our study suggests that sleeping for seven to eight hours a night is a good habit for lowering the risk of PAD,” said study author Dr. Shuai Yuan of the Karolinska Institute, Stockholm, Sweden.

More than 200 million people globally have peripheral artery disease (PAD), where arteries in the legs are clogged, restricting blood flow and increasing the risk of stroke and heart attack.

Dr. Yuan said, “Insufficient night-time sleep and daytime napping have previously been associated with a raised risk of coronary artery disease which, like PAD, is caused by clogged arteries. In addition, sleeping problems are among the top ranked complaints in PAD patients. There are limited data on the impact of sleep habits on PAD and vice versa, and our study aimed to fill that gap.”

The study included more than 650,000 participants. First, the researchers analyzed the associations of sleep duration and daytime napping with the risk of PAD. In the second part, the investigators used genetic data to perform naturally randomized controlled trials—called Mendelian randomization—to examine causality of the associations.

Taken together, the strongest evidence was for short sleep, where the relationship with PAD went both ways. In an observational analysis of 53,416 adults, sleeping less than five hours a night was associated with a nearly doubled risk of PAD compared with seven to eight hours.

Regarding long sleep, in an observational analysis of 53,416 adults, sleeping eight hours or more per night was linked with a 24% higher risk of PAD compared with seven to eight hours. 

Similar results were reported for napping, where daytime nappers had a 32% higher risk of PAD compared to those who did not nap but no causal links were found. 

Prenatal cigarette, cannabis exposure may have associations with childhood obesity

Pennsylvania State University & University of Missouri, March 16,2023

Childhood obesity rates continue to rise in the United States, putting kids at risk for asthma, sleep apnea, type 2 diabetes, and other health conditions. Children prenatally exposed to both tobacco and cannabis had a 12 times higher risk for obesity by middle childhood (9–12 years of age) compared to non-exposed children, according to recent research, although more research is needed to determine if other factors account for these findings.

Two of the most commonly used substances during pregnancy are cigarettes and cannabis, and they are often used together. While we know about the risks of prenatal tobacco exposure and child obesity, less is known about co-exposure to tobacco and cannabis. 

In the larger study, all pregnant women receiving prenatal care at an urban hospital located in western New York completed a health screener. Eligible women who use cannabis and/or tobacco were invited to complete detailed measures of substance use and provide biological samples that were tested for substance use.

Pregnant participants were then assessed at the end of each trimester, with 259 women completing laboratory visits with their child at approximately 2, 9, 16 and 24 months of child age, and again after the child entered kindergarten and during mid-childhood.

“We found that children in both exposure groups had a steeper increase in BMI trajectories from birth to mid-childhood, but among co-exposed children, girls had a steeper BMI increase compared with boys of the same age,” Kong said. “Overall, we found 12 times higher odds of having obesity among those co-exposed than those non-exposed to tobacco and cannabis. Children in the co-exposed group also had significantly greater fat mass and fat mass percent compared with non-exposed children. Children exposed only to tobacco were not different in fat mass compared to non-exposed children.”

Ginseng Provides Natural Help For Hair Loss

Seowon University (South Korea), March 15,  2023

The two FDA-approved medications for hair loss come with a risk of significant side effects. Ginseng provides a powerful natural alternative

By the age of 35, two-thirds of men have some degree of hair loss. By the age of 50, this rises to 85%. While often considered primarily a condition that affects men, women also struggle with hair loss. In fact, up to 40% of hair loss sufferers in the U.S. are women.

The U.S. Food and Drug Administration has approved two medications to treat hair loss. minoxidil (brand name Rogaine) is approved for men and women while finasteride (Propecia) is approved for men only. When minoxidil is stopped, hair loss returns, while finasteride may cause sexual dysfunction in men — and can lead to infertility and birth defects in women.[iv]

Ginseng’s group of saponin compounds known as ginsenosides have received considerable attention for their health-promoting effects. In terms of hair loss, ginsenosides may promote hair growth by enhancing proliferation of hair follicles and preventing hair loss by modulating various cell-signaling pathways.

While regular sun exposure is important for good health, excessive exposure to ultraviolet radiation from the sun has been implicated in causing damage to the hair shaft and altering the hair growth cycle. Specifically, ultraviolet irradiation leads to the accumulation of reactive oxygen species (ROS) and activates tissue-degrading enzymes known as matrix metalloproteinases (MMPs).

Certain ginsenosides have been found to reduce the formation of ROS and the secretion of certain MMPs in human skin cells following exposure to UVB radiation. “The inhibitory effect of ginsenosides on UVB-induced activation of MMP2 suggests the potential of these ginseng saponins in hair-growth regulation,” Choi explained.

Ginseng has impressive antioxidant, anti-inflammatory and antiaging properties, which translate to beneficial effects on hair growth. Choi highlighted several additional pathways by which ginseng may promote hair growth and prevent hair loss:

  • TGF-β — Transforming growth factor-beta (TGF-β) is a protein involved in activating hair follicle cells to create new cells or initiate apoptosis, or cell death. Ginseng modulates TGF-β signaling, and red ginseng extract has been found to decrease TGF-β1 levels while ginsenosides downregulate TGF-β-pathway-related genes, leading to hair growth-promoting effects.[xii]
  • 5α-reductase (5αR) –Treatment with 5α-reductase inhibitor drugs, such as finasteride, prevents the development of hair loss and increases growth of hair on the scalp. Ginsenosides have been found to inhibit 5α-reductase, leading to enhanced hair growth.
  • Interleukin 17 — Interleukin 17 (IL-17) is an inflammatory signaling molecule known to cause skin inflammation. IL-17A is thought to be involved in alopecia areata, or patchy baldness. Ginsenosides help regulate IL-17 secretion and may thereby help to enhance hair growth.

Mediterranean diet cuts women’s cardiovascular disease and death risk by nearly 25%, finds study

British Medical Journal, March 13, 2023

Sticking closely to a Mediterranean diet cuts a woman’s risks of cardiovascular disease and death by nearly 25%, finds a pooled data analysis of the available evidence—the first of its kind—published online in the journal Heart.

The findings prompt the researchers to call for more sex-specific research to guide clinical practice in heart health.

To build on the evidence base to inform sex specific guidance and clinical practice, the researchers trawled research databases for studies looking at the potential impact of eating a Mediterranean diet on women’s cardiovascular health and their risk of death.

From an initial haul of 190 relevant studies, the researchers included 16 publishedin their pooled data analysis.

The studies, which were mostly carried out in the US and Europe, involved more than 700,000 women aged 18 and above whose cardiovascular health was monitored for an average of 12.5 years.

The results of the analysis showed that sticking closely to a Mediterranean diet was associated with a 24% lower risk of cardiovascular disease, and a 23% lower risk of death from any cause in women.

The risk of coronary heart disease was 25% lower, while that of stroke was also lower, although not statistically significant, in those who most closely followed this diet compared with those who did so the least.

The Mediterranean diet’s antioxidant and gut microbiome effects on inflammation and cardiovascular risk factors are among the possible explanations for the observed associations, say the researchers. And the diet’s various components, such as polyphenols, nitrates, omega-3 fatty acids, increased fiber intake and reduced glycemic load, may all separately contribute to a better cardiovascular risk profile, they suggest.