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Scandal Behind the FDA “Fake Approval” of Pfizer Jab
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Star Trek Versus Imperialist Doctrine
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GOODBYE ‘ROE,’ HELLO VIOLENCE AND AN OUT-OF-CONTROL JUDICIARY
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Nemesis: Why the west was doomed to lose in Afghanistan
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ACIP vote yesterday after deceitful CDC briefings removes liability from Comirnaty, opening the door to mandates
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Afghanistan collapse reveals Beltway media’s loyalty to permanent war state
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Sand is one of our most used resources, but the industry is not sustainable
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Climate-Driven Weather Disasters Increased Fivefold Over Past 50 Years: UN Agency
Todays Videos:
1. Dr. Ryan Cole #StoptheMandate 24.12 – 28.33
2. Peter McCullough, MD testifies to Texas Senate HHS Committee start 12:24
3. If by Rudyard Kipling – Read by Sir Michael Caine
4. Australia painted as a ‘dystopian nightmare’ as footage goes viral
Eating red grapes can help fight off cancer
Pennsylvania State University, August 27, 2021
According to a study by researchers at The Pennsylvania State University (PennState), the combination of resveratrol from the skin of red grapes and the phenolic compounds in grape seed extract can stop the development of tumors and even kill colon cancer stem cells. These immortal cells are known as the “seeds of cancer” because of their unlimited capacity to self-renew and proliferate and their role in tumor formation. At present, there are no mainstream drugs that can kill cancer stem cells.
The beneficial compounds in grapes
Resveratrol is a botanical compound that can be found in a variety of berries, such as blueberries, bilberries and cranberries. But it is strongly associated with red grapes and red wine because they contain the highest resveratrol levels among known sources. Resveratrol only resides in the skins of red grapes, so only wines that are produced without removing grape skins early on contain this beneficial compound.
Resveratrol is a polyphenolic compound that belongs to the stilbenes, a group of plant chemicals known for their antioxidant, anti-inflammatory and anti-cancer properties. It is also considered a phytoalexin because plants produce it in response of environmental stressors. A plethora of studies have linked various health benefits to resveratrol, such as blood pressure and blood cholesterol reduction, brain protection from age-related cognitive decline, improved insulin sensitivity and cancer prevention.
Aside from resveratrol, plenty of other polyphenols can be found in grapes, particularly in their seeds. Chemical analyses revealed that grape seed extracts are rich in flavonoids and other stilbenes, which also give them an abundance of health-promoting properties. According to studies, grape seed extracts can help lower blood pressure, improve blood circulation, protect healthy cells from oxidative damage, fight microbial infections and reduce cancer risk, among other benefits.
Grape compounds can help prevent cancer
In an earlier study, PennState researchers found that at high concentrations, resveratrol can increase the effectiveness of grape seed extract against colon cancer cells. This led them to hypothesize that this combo could also work against cancer stem cells, which are responsible for the resistance shown by certain tumors to chemotherapy and radiation. To their knowledge, no other study has tested the potency of these combinations against colon cancer stem cells.
For their experiment, the researchers treated cultured human colon cancer stem cells with resveratrol and grape seed extract. They also used mice with chemically induced colon cancer to see if the combination could prevent tumor formation under biological conditions.
The researchers found that the resveratrol-grape seed extract combo suppressed the growth of tumors in the treated mice without causing any stomach issues. They also found that the grape compounds managed to reduce the number of colon crypts containing cancer stem cells by causing the stem cells to commit cell suicide (apoptosis).
Meanwhile, in culture, the researchers also observed that the combination of resveratrol and grape seed extract prevented colon cancer stem cells from proliferating and forming spheres. Sphere formation is a sign of self-renewal and is linked to tumor development. Unlike the conventional anti-tumor drug sulindac, the combination of resveratrol and grape seed extract also effectively killed colon cancer stem cells by activating molecular pathways that led to apoptosis.
Thanks to these findings, the researchers were convinced that the bioactive compounds in grapes can be used for the prevention and treatment of colon cancer.
“The combination of resveratrol and grape seed extract is very effective at killing colon cancer cells. And what we’re learning is the combination of these compounds is not toxic to healthy cells,” said Jairam Vanamala, an associate professor of food science at PennState and one of the study authors.
Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials
Newcastle University (UK), August 26, 2021
According to news reporting out of Callaghan, Australia, research stated, “Chronic inflammation is a major contributor to the development of noncommunicable diseases. Curcumin, a bioactive polyphenol from turmeric, is a well-known anti-inflammatory agent in preclinical research.”
Our news journalists obtained a quote from the research from Newcastle University, “Clinical evidence remains inconclusive because of discrepancies regarding optimal dosage, duration, and formulation of curcumin. The aim of this systematic review, conducted and reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and checklist, was to evaluate the efficacy of curcumin supplementation on systemic inflammatory mediators, comparing dose, duration, and bioavailability status of interventions. The Medline, CINAHL, EMBASE, Scopus, and Cochrane literature databases were searched from 1980 to May-end 2019. Randomized controlled trials investigating effects of dietary curcumin on inflammatory mediators in humans not receiving anti-inflammatory treatment were eligible for inclusion. Two authors independently assessed titles and abstracts of identified articles for potential eligibility and respective, retrieved, full-text articles; disagreements were resolved by a third author. Evidence quality was critically appraised using the Quality Criteria Checklist for Primary Research. Thirty-two trials (N = 2,038 participants) were included and 28 were meta-analyzed using a random-effects model; effect sizes were expressed as Hedges’ g (95%CI). Pooled data (reported here as weighted mean difference [WMD]; 95%CI) showed a reduction in C-reactive protein (-1.55 mg/L; -1.81 to -1.30), interleukin-6 (-1.69 pg/mL, -2.56 to -0.82), tumor necrosis factor a (-3.13 pg/mL; -4.62 to -1.64), IL-8 (-0.54 pg/mL; -0.82 to -0.28), monocyte chemoattractant protein-1 (-2.48 pg/mL; -3.96 to -1.00), and an increase in IL-10 (0.49 pg/mL; 0.10 to 0.88), with no effect on intracellular adhesion molecule-1.”
According to the news editors, the research concluded: “These findings provide evidence for the anti-inflammatory effects of curcumin and support further investigation to confirm dose, duration, and formulation to optimize anti-inflammatory effects in humans with chronic inflammation. PROSPERO
Mediterranean diet associated with ED improvement
University of Athens (Greece) August 30 2021.
Research reported at the European Society of Cardiology (ESC) Congress 2021, held August 27-30, revealed a beneficial effect of consuming a Mediterranean diet on erectile function in men with high blood pressure. “Erectile dysfunction (ED) often coexists in the hypertensive aging male population where endogenous testosterone typically declines,” observed researchers Athanasios Angelis of the University of Athens and colleagues.
The study included 250 hypertensive men with ED. Questionnaire responses provided information concerning adherence to a Mediterranean diet, which is characterized by a high intake of vegetables, fruit, whole grains, legumes, fish, lean meat and olive oil, a moderate intake of dairy products and wine, and low amounts of red meat and saturated fat. Exercise capacity (assessed by treadmill testing), coronary flow reserve (the ability to increase blood flow when needed) of the left anterior descending artery, measures of arterial stiffness, blood testosterone levels and ED severity were evaluated.
Participants who had a higher Mediterranean diet score had better coronary flow reserve, higher testosterone levels, increased erectile performance and less arterial stiffness in comparison with men who had lower scores. Men who had greater exercise capacity were also found to have better erectile function and other factors.
“In our study, consuming a Mediterranean diet was linked with better exercise capacity, healthier arteries and blood flow, higher testosterone levels, and better erectile performance,” Dr Angelis stated. “While we did not examine mechanisms, it seems plausible that this dietary pattern may improve fitness and erectile performance by enhancing function of the blood vessels and limiting the fall in testosterone that occurs in midlife.”
“The findings suggest that the Mediterranean diet could play a role in maintaining several parameters of vascular health and quality of life and in middle aged men with hypertension and erectile dysfunction,” he concluded.
People often avoid feeling compassion for others, feel it’s a lot of effort
Penn State University, August 31, 2021
Compassion helps us relate to and feel sympathy for others as they experience hardships, but a new study suggests some people may actively avoid feeling compassion when given the choice.
In a series of studies, the researchers found that when given the option, people often chose to avoid feeling compassion for others and reported that doing so was mentally effortful, which were linked to their choices. However, the researchers also found that if the situation involved a person they were close to, such as a family member, people were more likely to choose to feel compassion and that being compassionate in this context was easier.
Julian Scheffer, a Penn State graduate and postdoctoral research fellow at University of California, Berkeley, said the findings suggest a need for new ways to encourage people to open themselves up to feeling compassion for others—especially in times of division and hardship.
“Experiencing compassion often leads to wanting to help others and improve their welfare, but we found that people may be unwilling to experience compassion and find it mentally taxing,” Scheffer said. “Knowing when effort matters for compassion can help inform how we think about weaker compassionate responses, whether in response to a stranger or even mass suffering, as in the case of the COVID-19 pandemic.”
Daryl Cameron, associate professor of psychology and senior research associate at Rock Ethics Institute, said the studies were among the first to examine how and when people choose to feel compassion.
“These choices track with felt cognitive costs,” Cameron, also director of the Empathy & Moral Psychology Lab, said, “so cultivating compassion for your family may feel easier than cultivating compassion for a stranger, and this may be one reason why people tend to show such biases in their compassionate responding.”
Scheffer added that one solution could be preparing people to take on compassion’s mental demands, which might help people be willing to experience it. Otherwise, compassion may be harder to approach than once imagined.
“Oftentimes, people are asked to have empathy or compassion for others, with the idea that these feelings will lead to more openness, cooperation, and a willingness to help those who are suffering,” Scheffer said. “We wanted to examine how people choose to engage with these emotional processes, whether they would be approached or avoided, and why this would be the case.”
To explore these questions, the researchers performed a series of studies with the number of participants ranging from 62 to 215 in each. They designed three virtual card decks that participants could choose from and would instruct their response to other people—one that asked them to feel compassion for the person on the card, one that asked them to feel empathy, and one that asked them to remain objective and simply describe the person—that the researchers then used in several experiments.
While compassion and empathy may have similarities, Scheffer said, some separate compassion as feelings of caring or sympathy for another person, while empathy is thought to involve taking on another person’s suffering and experiences as if they were your own.
In the first two studies, participants were split into two groups. One was asked to choose between drawing from the compassion or objective decks, and the other was asked to choose between the empathy and objective decks. Participants chose the compassion deck over the objective deck only about 25% of the time in the first study and about 21% in the second. Additionally, they chose the empathy deck about 30% and 29% of the time in each study, respectively.
Next, participants were asked to choose between drawing from the compassion or empathy decks. This time, people were more likely to choose empathy over compassion. However, when they could choose between the empathy, compassion and objective decks, participants were more likely to opt to remain objective.
“Some psychologists and philosophers have said compassion is easier than empathy,” Cameron said. “One way to test that assumption is to directly compare them and give people a choice. When we asked people if they wanted to feel compassion, at least for strangers, they typically didn’t want to and found it more challenging than empathy.”
Finally, participants were once again presented with the decks as in previous experiments, but this time instead of the decks containing images of strangers, they included cards with the names of people each participant either knew very well or were just acquainted with.
“We found that people were more willing to experience compassion for their loved ones compared to strangers, and this linked with experiencing reduced difficulty with compassion for loved ones,” Scheffer said. “Compassion may be more desirable when directed toward more familiar loved ones, and potentially feel less difficult.”
Scheffer said he hopes the findings—recently published in the Journal of Experimental Psychology: General—will give insight about why some might resist experiencing compassion for others, despite it being considered a generally positive feeling.
“More people are finding it increasingly difficult to engage with each other, and as people are overwhelmed with the amount of suffering right now due to the pandemic, it may make compassion particularly difficult,” Scheffer said. “Finding ways to better manage the mental challenges of compassion may provide a more rewarding route to generating prosocial motivation, especially in this particularly troubling time.”
Greater dietary intake of tocopherols associated with lower risk of disabling dementia
Tsukuba University (Japan) and University College London, August 30, 2021
According to news reporting from the University of Tsukuba research stated, “Tocopherols, strong antioxidants, may be useful in preventing dementia, but the epidemiological evidence is insufficient. We performed a community-based follow-up study of Japanese, the Circulatory Risk in Community Study, involving 3739 people aged 40-64 years at baseline (1985-1999).”
The news correspondents obtained a quote from the research from University of Tsukuba: “Incident disabling dementia was followed up from 1999 through 2020. For subtype analysis, we classified disabling dementia into that with and that without a history of stroke. Dietary intake of tocopherols (total, a, b, g, and d) were estimated using 24-h recall surveys. During a median follow-up of 19.7 years, 670 cases of disabling dementia developed. Total tocopherol intake was inversely associated with risk of disabling dementia with multivariable hazard ratios (95% confidence intervals) of 0.79 (0.63-1.00) for the highest versus lowest quartiles of total tocopherol intake (P for trend = 0.05). However, the association was strengthened when further adjusted for a-linolenic acid intake (Spearman correlation with total tocopherol intake = 0.93), with multivariable hazard ratios of 0.50 (0.34-0.74) (P for trend = 0.001) but was weakened and nonsignificant when further adjusted for linoleic acid intake (Spearman correlation with total tocopherol intake = 0.92), with multivariable hazard ratios of 0.69 (0.47-1.01) (P for trend = 0.05). Similar but nonsignificant inverse associations were observed for a-, g-, and d-tocopherols but not for b-tocopherol. These results were similar regardless of the presence of a history of stroke.”
According to the news reporters, the research concluded: “Dietary tocopherol intake was inversely associated with risk of disabling dementia, but its independent effect was uncertain owing to a high intercorrelation of a-linolenic linoleic acids with total tocopherol intake. Even with such confounding, a diet high in tocopherols may help prevent the onset of dementia.”
Eating protein three times a day could make our seniors stronger
McGill University Health Center (Montreal), August 31, 2021
Loss of muscle is an inevitable consequence of aging that can lead to frailty, falls or mobility problems. Eating enough protein is one way to remedy it, but it would seem that spreading protein equally among the three daily meals could be linked to greater mass and muscle strength in the elderly. These are the findings of a study conducted at the Research Institute of the McGill University Health Centre (RI-MUHC) in collaboration with the Université de Sherbrooke and the Université de Montréal. The research team examined both the amount of protein consumed and its distribution among people aged 67 and over, using one of the most comprehensive cohort studies in Quebec.
The results of the study, which were published in the American Journal of Clinical Nutrition, shed new light on the diet of people in an aging population.
“Many seniors, especially in North America, consume the majority of their daily protein intake at lunch and dinner. We wanted to see if people who added protein sources to breakfast, and therefore had balanced protein intake through the three meals, had greater muscle strength,” says the lead author of the study, Dr. Stéphanie Chevalier, who is a scientist with the Metabolic Disorders and Complications Program at the RI-MUHC and an assistant professor at the School of Human Nutrition at McGill University.
A rich database of nutrition data
To achieve these results, Dr. Chevalier and her team collaborated with the Université de Sherbrooke and used the database from the Quebec longitudinal study on nutrition and aging called NuAge (Nutrition as a Determinant of Successful Aging).
RI-MUHC researchers analyzed data from the NuAge cohort, which included nearly 1,800 people who were followed for three years. They reviewed the protein consumption patterns of 827 healthy men and 914 healthy women aged 67 to 84 years, all residents of Quebec, trying to establish links with variables such as strength, muscle mass or mobility.
“The NuAge study is one of the few studies gathering such detailed data on food consumption among a large cohort of elderly people. We are proud that the NuAge study can contribute to relevant research of this magnitude in Quebec,” says study co-author Dr. Hélène Payette of the Centre for Research on Aging and a professor at the Faculty of Medicine at the Université de Sherbrooke.
“We observed that participants of both sexes who consumed protein in a balanced way during the day had more muscle strength than those who consumed more during the evening meal and less at breakfast. However, the distribution of protein throughout the day was not associated with their mobility,” explains the first author of the study, Dr. Samaneh Farsijani, a former PhD student at the RI-MUHC supervised by Dr. Chevalier.
A “boost” of amino acids
All body tissues, including the muscles, are composed of proteins, which consist of amino acids. If the protein intake decreases, the synthesis is not done correctly and this leads to a loss of muscle mass.
“Our research is based on scientific evidence demonstrating that older people need to consume more protein per meal because they need a greater boost of amino acids for protein synthesis,” says Dr. Chevalier, adding that one of the essential amino acids known for protein renewal is leucine. “It would be interesting to look into protein sources and their amino acid composition in future studies to further our observations.”
Suicide risk linked to push for perfection
University of Western Ontario, August 31, 2021
People who believe they must be perfect – and who ultimately can’t deal with the thought of being flawed – are at much greater risk of suicidal thoughts and suicide, according to a recent Western co-authored study.
“We tend to think of perfectionism as potentially a good thing. We’re told, ‘Aim high, reach for the stars,'” said Psychology PhD candidate Martin Smith, lead investigator on the study. “But for some people, even excellence isn’t good enough, and that’s where they run into issues. Insisting on flawlessness is simply not mentally healthy, adaptive or advisable.”
The Perniciousness of Perfectionism was recently published in Journal of Personality.
Smith and his team drew together 45 studies and 54 samples representing almost 12,000 participants in the most comprehensive analysis to date of the perfectionism-suicide link. The study notes that 10-20 million people attempt suicide each year and nearly one million people die by suicide. And while suicide rarely has one single cause, perfectionism must now be added to the list of potential contributing concerns, he said.
“We can’t at this point say perfectionism is a cause of suicide. But we can say the two correlate closely,” he said. “The drive to be perfect – whether it’s because of internal or external pressure to succeed without ever failing – can be an unbearable and untenable strain.”
People intent on perfection often fly below professionals’ radar because seeking help is an admission they are imperfect, he said.
The researchers said the study can help clinicians be more aware of an array of suicidal markers and develop preventive measures.
“Our findings join a wider literature suggesting that, when people experience their social world as pressure-filled, judgmental, and hyper-critical, they think about and/or engage in various potential means of escape (e.g., alcohol misuse and binge eating), including suicide,” the study stated.
