Active Component of Grape Seed Extract Effective Against Cancer Cells
University of Colorado Cancer Center, June 13 2022
A University of Colorado Cancer Center study published online ahead of print in the journal Nutrition and Cancer describes the laboratory synthesis of the most active component of grape seed extract, B2G2, and shows this synthesized compound induces the cell death known as apoptosis in prostate cancer cells while leaving healthy cells unharmed.
“We’ve shown similar anti-cancer activity in the past with grape seed extract (GSE), but now we know B2G2 is its most biologically active ingredient which can be synthesized in quantities that will allow us to study the detailed death mechanism in cancer cells,” says Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences.
The group pinpointed B2G2 as the most active compound, but, “it’s expensive and it takes a long time to isolate B2G2 from grape seed extract,” Tyagi says.
This expense related to the isolation of B2G2 has limited the group’s further exploration. So instead of purifying B2G2 from GSE, the group decided to synthesize it in the lab. The current study reports the success of this effort, including the ability to synthesize gram-quantity of B2G2 reasonably quickly and inexpensively.
In the paper’s second half, the group shows anti-cancer activity of synthesized B2G2 similar in mechanism and degree to overall GSE effectiveness.
Improving Memory Naturally: Sage Contains Similar Compounds as Modern Alzheimer’s Drugs
Newcastle and Northumbria Universities, June 14 2022
Sage was named “Herb of the Year” in 2001 by the International Herb Association.
Some of the latest research shows how sage can boost memory and cognitive health. The leaves and stems of sage contain these antioxidant enzymes that protect against free radical oxidative cell damage as well as provide inflammatory relief from ailments such as arthritis and asthma.
The Medicinal Plant Research Centre (MPRC) of England conducted studies at Newcastle and Northumbria Universities with sage oil herb pills against placebo pills. Those who took the sage performed much better with a word recall test than those who took the placebo.
In the long run, home-made tinctures are the most economical way to have and use highly effective tinctures for a long time.
Trade the chair for fresh air: Study explores link between sitting time and cardio health
Simon Fraser University (Canada), June 15 2022
New research is adding further weight to the argument that prolonged sitting may be hazardous to your health. An international study surveying more than 100,000 individuals in 21 countries found that people who sat for six to eight hours a day had a 12–13 percent increased risk for early death and heart disease, while those who sat for more than eight hours daily increased that to a sobering 20 percent.
Their research followed individuals over an average of 11 years and determined that high amounts of sitting time were associated with increased risk of early death and cardiovascular disease.
Not surprising, those who sat the most and were the least active had the highest risk—up to 50 percent—while those who sat the most but were also the most active had a substantially lower risk of about 17 percent.
“For those sitting more than four hours a day, replacing a half hour of sitting with exercise reduced the risk by two percent,” Lear notes. “With only one in four Canadians meeting the activity guidelines there’s a real opportunity here for people to increase their activity and reduce their chances of early death and heart disease.”
Acupuncture Can Treat Alzheimer’s Disease
Hubei University of Chinese Medicine (China), June 5, 2022
An increasing number of clinical and animal studies have confirmed that acupuncture is effective for the treatment of Alzheimer’s disease. Moxibustion is reported to be more effective than electro-acupuncture for improving space-recognizing memory ability in aged mice, suggesting that moxibustion is another alternative or complementary therapy used to treat Alzheimer’s disease.
Dr. Yanjun Du and team from Hubei University of Chinese Medicine, China only used suspended moxibustion (also named warming moxibustion, scarring moxibustion, or herb-partition moxibustion) on Baihui and Shenshu acupoints to observe the action of pre-moxibustion on preventing apoptosis in a rat model of Alzheimer’s disease.
Men and women with brain condition could be helped by vitamin E
Cangzhou Central Hospital (China), June 15 2022.
Leukoaraiosis is an abnormality in the brain’s white matter that appears on magnetic resonance imaging (MRI) as white matter hyperintensities. In an article published in the International Journal of Neuroscience, researchers at Cangzhou Central Hospital in Hebei, China reported improvements in factors related to leukoaraiosis among adults given supplements containing vitamin E.
“Leukoaraiosis (LA) is a disease manifested by demyelination and gliosis in white matter, mainly caused by cerebrovascular diseases,” Yan Wang and colleagues wrote. “Leukoaraiosis is closely related to the expression level of inflammatory factors, oxidative stress, and vascular endothelial dysfunction in patients. Vitamin E may play antioxidant and anti-inflammatory roles in various diseases.”
Participants received 200 IU, 400 IU or 600 international units (IU) vitamin E or a placebo daily for 12 weeks. At the end of the treatment period, blood samples were evaluated for the inflammatory factors C-reactive protein, complement C3 and C4, and matrix metalloproteins 2 and 9, as well as for markers of oxidative stress and endothelial function (function of the lining of the arteries, which is impaired in cerebrovascular and cardiovascular disease).
Inflammation, oxidative stress and endothelial function improved in all groups that received vitamin E in comparison with the placebo. Cognitive function scores also significantly improved in the vitamin E-treated groups. Improvement in all measured factors was correlated with higher doses of vitamin E.
Chlorogenic acid plus chromium improves insulin resistance and lowers obesity in mice
University of Toledo, June 10 2022
In an article published in Nutrition & Metabolism, University of Toledo researchers report that a combination of chromium and chlorogenic acid (CGA), a polyphenol occurring in coffee, reversed the development of obesity and insulin resistance in mice caused by the intake of a high-fat diet.
Sonia M. Najjar and her associates fed male BL6 mice a standard diet or a high-fat diet for seven weeks. During the last three weeks of the diet, the high-fat group received a daily oral supplement containing water, chlorogenic acid, or a combination of chlorogenic acid and chromium in a base that contained caffeine. Body weight was measured weekly, insulin tolerance was assessed at four and seven weeks, and glucose and glucose tolerance were assessed at the end of the treatment period.
At four weeks, animals supplemented with chlorogenic acid and the combination of chlorogenic acid and chromium experienced weight loss within two weeks, and attained weights comparable to those of animals that received a standard diet. While insulin resistance after four weeks was greater among high-fat diet-fed mice compared to those fed a standard diet, supplementation with chlorogenic acid plus chromium reduced this effect, and restored it to a level comparable to that of standard-diet-fed mice. Glucose tolerance and glucose levels were similarly restored in animals that received the supplement combination.